2-MORPHOLINO-4H-PYRIMIDO[2,1-A]ISOQUINOLIN-4-ONE 2-吗啉基-4H-嘧啶并[2,1-A]异喹啉-4-酮

中文名	Compound 401
英文名	Compound 401
别名	化合物COMPOUND 401 2-吗啉基-4H-嘧啶并[2,1-A]异喹啉-4-酮 2-(吗啉-4-基)嘧啶并[2,1-A]异喹啉-4-酮 2-MORPHOLINO-4H-PYRIMIDO[2,1-A]ISOQUINOLIN-4-ONE 2-吗啉基-4H-嘧啶并[2,1-A]异喹啉-4-酮
英文别名	CS-315 COMPOUND401 Compound 401 COMPOUND-401 2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one 2-(Morpholin-4-yl)pyrimido[2,1-a]isoquinolin-4-one 2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one 4H-PyriMido[2,1-a]isoquinolin-4-one, 2-(4-Morpholinyl)-
CAS	168425-64-7
化学式	C16H15N3O2
分子量	281.31
密度	1.36±0.1 g/cm3 (20 ºC 760 Torr)
熔点	184-186℃ (ethanol )
沸点	456.9±55.0 °C(Predicted)
酸度系数	1.01±0.20(Predicted)
存储条件	Store at RT
外观	粉末或结晶
颜色	White to Light yellow
体外研究	Compound 401 is a potent inhibitor of DNA-PK (IC 50 =0.28 μM). Compound 401 is reported to be a poor inhibitor of PI3K, ATM, and ATR in vitro, but it is active against mTOR. Compound 401 shows activity against mTOR (IC 50 =5.3 μM) but not p110α/p85α PI3K (IC 50 >100 μM). Treatment of cells with Compound 401 blocks the phosphorylation of sites modified by mTOR-Raptor and mTOR-Rictor complexes (ribosomal protein S6 kinase 1 Thr 389 and Akt Ser 473 , respectively). By contrast, there is no direct inhibition of Akt Thr 308 phosphorylation, which is dependent on PI3K. Similar effects are also observed in cells that lack DNA-PK. Compound 401 inhibits immunoprecipitated epitope-tagged mTOR or endogenous mTOR in Raptor immunoprecipitates. In both cases, inhibition of 67% or 78% is obtained at 5 μM or 10 μM Compound 401, respectively. By contrast, dose response curves show that the p110α/p85α or p110β/p85α PI3K complexes are poorly inhibited by Compound 401 at these concentrations. The proliferation of TSC1 -/- fibroblasts is inhibited in the presence of Compound 401, but TSC1 +/+ cells are resistant.

2-MORPHOLINO-4H-PYRIMIDO[2,1-A]ISOQUINOLIN-4-ONE 2-吗啉基-4H-嘧啶并[2,1-A]异喹啉-4-酮 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	3.555 ml	17.774 ml	35.548 ml
5 mM	0.711 ml	3.555 ml	7.11 ml
10 mM	0.355 ml	1.777 ml	3.555 ml
5 mM	0.071 ml	0.355 ml	0.711 ml

最后更新：2024-01-02 23:10:35

2-MORPHOLINO-4H-PYRIMIDO[2,1-A]ISOQUINOLIN-4-ONE 2-吗啉基-4H-嘧啶并[2,1-A]异喹啉-4-酮 - 简介

Compound 401也称为401化合物，是一种有机化合物。它是一种无色至浅黄色的液体，具有特殊的香味。

其用途，Compound 401被广泛应用于工业和实验室中的各种化学反应中，特别是用作常见的溶剂、溶媒和试剂。它在有机合成反应、萃取、结晶和洗涤等过程中发挥着重要作用。Compound 401还可以用作油墨和绘画材料中的溶剂。

制备Compound 401的方法可以通过苯基环氧乙烷和乙ylene oxide反应得到，或者通过苯与环氧乙烷的加成反应制备。

最后更新：2024-04-09 21:54:55

2-MORPHOLINO-4H-PYRIMIDO[2,1-A]ISOQUINOLIN-4-ONE 2-吗啉基-4H-嘧啶并[2,1-A]异喹啉-4-酮

北京索莱宝科技有限公司

现货供应

产品名: Compound401 去供应商网站查看询盘
CAS: 168425-64-7
产地: 北京
包装: 盒
规格: IC3260-5mg,5mg,IC3260-10mg,10mg
价格: 电话、微信、QQ、邮件
库存: 现询
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上海吉至生化科技有限公司

现货供应

产品名: Compound 401 去供应商网站查看询盘
CAS: 168425-64-7
产地: 中国上海
包装: 100mg
规格: 99%
价格: 7898.00
库存: 现货
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产品描述: 中文名：Compound 401 英文名:Compound 401 CAS:168425-64-7 规格:99% 产地:中国上海

上海麦克林生化科技股份有限公司

现货供应

产品名: 2-吗啉基-4H-嘧啶并[2,1-a]异喹啉-4-酮去供应商网站查看询盘
CAS: 168425-64-7
产地: 上海
规格: M794290
价格: 1ml-376,10mg-42
库存: 15天内发货
电话: 13816333479/13918391375
手机: 13816333479/13918391375
电子邮件: wangrui@macklin.cn
QQ: 2885703204/285395191

微信: 19863730987/13918391375

上海源叶生物科技有限公司

现货供应

产品名: Compound 401 去供应商网站查看询盘
CAS: 168425-64-7
产地: 上海
规格: 99%
价格: 1mg 192,5mg 320,10mg 472,25mg 960,50mg 1520,100mg 2880
库存: 现货
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